Ganglioside GT1b (bovine) (sodium salt) (Synonyms: Ganglioside G1, Trisialoganglioside GT1b)

Ganglioside G_T1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC₅₀ values of 11, 0.74, and 7.2 μM, respectively.¹ Ganglioside G_T1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside G_T1b as a putative MCPyV receptor.² Ganglioside G_T1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM.³ This product contains ganglioside G_T1b molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1558]

1.Schengrund, C.-L., DasGupta, B.R., and Ringler, N.J.Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereofJ. Neurochem.57(3)1024-1032(1991) 2.Erickson, K.D., Garcea, R.L., and Tsai, B.Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirusJ. Virol.83(19)10275-10279(2009) 3.Kanda, N., and Tamaki, K.Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cellsImmunology96(4)628-633(1999)