Ganoderol B (Synonyms: Ganodermadiol, (+)-Ganoderol B)

Ganoderol B is a triterpenoid that has been found in G. lucidum and has diverse biological activities.^1,2,3,4,5 It inhibits angiotensin-converting enzyme (ACE) and α-glucosidase (IC₅₀s = 220 and 119.8 µM, respectively).^1,2 Ganoderol B is cytotoxic to HGC-27 gastric, HeLa cervical, and A549 lung cancer cells (IC₅₀s = 16.15, 12.64, and 9.77 µM, respectively).³ It prevents herpes simplex virus 1 (HSV-1) infection in Vero cells (EC₅₀ = 68 µM).⁴ Ganoderol B (0.001 and 0.1 mg/kg) reduces testosterone-induced increases in ventral prostate weight in castrated rats.⁵

1.Morigiwa, A., Kitabatake, K., Fujimoto, Y., et al.Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidumChem. Pharm. Bull. (Tokyo)34(7)3025-3028(1986) 2.Fatmawati, S., Shimizu, K., and Kondo, R.Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidumPhytomedicine18(12)1053-1055(2011) 3.Su, H.-G., Zhou, Q.-M., Guo, L., et al.Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell linesPhytochemistry15689-95(2018) 4.Mothana, R.A.A., Ali, N.A.A., Jansen, R., et al.Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferiFitoterapia74(1-2)177-180(2003) 5.Liu, J., Shimizu, K., Konishi, F., et al.The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidumBioorg. Med. Chem.15(14)4966-4972(2007)