6-Thioinosine |
| カタログ番号GC35171 |
6-チオイノシン (6TI) はプリン代謝拮抗物質であり、抗脂肪生成剤として作用し、PPAR γ および C/EBPα の mRNA レベル、ならびに LPL、CD36、aP2、および LXRα などの PPAR γ 標的タンパク質をダウンレギュレートします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 574-25-4
Sample solution is provided at 25 µL, 10mM.
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6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].
[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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