E3 ligase Ligand 14 |
| カタログ番号GC35928 |
E3 リガーゼ リガンド 14 は、E3 ユビキチン リガーゼのリガンドです。 E3 リガーゼ リガンド 14 は、リンカーによってタンパク質のリガンドに接続され、PROTAC を形成します。 PROTAC は、がん促進タンパク質のユビキチン化を介した分解のインデューサーです。
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Cas No.: 2241489-43-8
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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