Sumanirole maleate (Synonyms: PNU 95666) |
| カタログ番号GC37702 |
マレイン酸スマニロール (U-95666E; PNU-95666E) は、約 46 nM の ED50 を持つ高度に選択的な D2 受容体完全アゴニストです。
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Cas No.: 179386-44-8
Sample solution is provided at 25 µL, 10mM.
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Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
[1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587
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