DNA2 inhibitor C5 |
| カタログ番号GC38207 |
DNA2 阻害剤 C5 は、DNA2 ヌクレアーゼ活性の強力で競合的かつ特異的な阻害剤であり、IC50 は 20 μM です。 DNA2 阻害剤 C5 は、ヌクレアーゼ、DNA 依存性 ATPase、ヘリカーゼ、および DNA2 の DNA 結合活性を阻害します。 DNA2 阻害剤 C5 は、複製ストレスを引き起こすがん化学療法の増感剤を開発するための有望なリード化合物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35973-25-2
Sample solution is provided at 25 µL, 10mM.
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DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].
[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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