Masupirdine mesylate (Synonyms: SUVN-502 mesylate) |
| カタログ番号GC38509 |
マスピルジン メシル酸塩 (SUVN-502 メシル酸塩) は、強力で、選択的で、経口で生物学的に利用可能な、脳浸透性の 5-HT6 受容体アンタゴニストです (ヒト 5-HT6 受容体に対する Ki は 2.04 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1791396-46-7
Sample solution is provided at 25 µL, 10mM.
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Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1].
[1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.
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