BPK-29 hydrochloride |
| カタログ番号GC38643 |
BPK-29 塩酸塩は、C274 を共有結合で修飾することにより、非定型オーファン核受容体 NR0B1-タンパク質 (RBM45 や SNW1 など) の相互作用を破壊する特異的なリガンドです。 BPK-29 塩酸塩は、KEAP1 変異がん細胞の足場非依存性増殖を阻害します。
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Cas No.: 2444815-73-8
Sample solution is provided at 25 µL, 10mM.
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BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].
BPK-29 hydrochloride substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
[1]. Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23.
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