Tiaprofenic Acid (Synonyms: RU 15060, Tiaprofen) |
| カタログ番号GC45579 |
チアプロフェン酸は、抗炎症作用と鎮痛作用を持つ経口活性非ステロイド性抗炎症薬 (NSAID) です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 33005-95-7
Sample solution is provided at 25 µL, 10mM.
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Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.1 It inhibits synthesis of prostaglandin E2 and PGF2α from arachidonic acid in bovine seminal vesicle microsomes and inhibits thromboxane B2 formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).2,1 Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.1
References
1. Sorkin, E.M., and Brogden, R.N. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs 29(3), 208-235 (1985).
2. Schr•r, K., and Seidel, H. Blood-vessel wall arachidonate metabolism and its pharmacological modification in a new in vitro assay system. Naunyn Schmiedebergs Arch. Pharmacol. 337(2), 177-182 (1988).
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