Glyphosate (Synonyms: NSC 151063) |
| カタログ番号GC60882 |
グリホサートは、アミノ酸グリシンの除草誘導体です。グリホサートは、植物の芳香族アミノ酸の合成に必要な、動物には見られない植物代謝経路であるシキミ酸経路を標的とし、遮断します。
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Cas No.: 1071-83-6
Sample solution is provided at 25 µL, 10mM.
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Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants[1].
Glyphosate is a high-efficiency, low-toxicity, broad-spectrum herbicide. The residues of glyphosate-based herbicides are frequent pollutants in the environment. Glyphosate exposure could interfere with mouse oocyte maturation by generating oxidative stress and early apoptosis.Glyphosate induces early apoptosis and autophagy in mouse oocytes[2].
[1]. Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45(3):185-208. [2]. Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435.
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