GS-626510 |
| カタログ番号GC33204 |
GS-626510 は強力な経口活性の BET ファミリー ブロモドメイン阻害剤で、BRD2/3/4 の Kd 値は 0.59 ～ 3.2 nM、BD1 と BD2 の IC50 値はそれぞれ 83 nM と 78 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1637770-13-8
Sample solution is provided at 25 µL, 10mM.
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GS-626510 is a potent, and orally bioavailable BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively[1].
[1]. Sperandio D, et al. Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg Med Chem. 2019 Feb 1;27(3):457-469.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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