Guvacoline (hydrobromide) (Synonyms: Norarecoline) |
| カタログ番号GC15845 |
心房および回腸ムスカリン受容体の完全アゴニスト
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Cas No.: 17210-51-4
Sample solution is provided at 25 µL, 10mM.
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Target: atrial and ileal muscarinic receptors
IC50: 2.1 mM for growth inhibition of human buccal epithelial cells
Guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. Guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.
In Vitro: In human buccal epithelial cells, Guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the IC50 value of 2.1 mM. Besides, Guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mM Guvacoline caused 25% decrease) and increase the number of single strand breaks [1].
In Vivo: No data available recently.
Clinical trial: No data available recently.
Reference:
[1] K. Sundqvist, Y. Liu, J. Nair, et al. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Research 49(19), 5294-5298 (1989).
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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