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Guvacoline (hydrobromide) Catalog No.GC15845

full agonist of atrial and ileal muscarinic receptors

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 17210-51-4 SDF
Synonyms Norarecoline
Chemical Name 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide
Canonical SMILES O=C(OC)C1=CCCNC1.Br
Formula C7H11NO2 • HBr M.Wt 222.1
Solubility ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Target: atrial and ileal muscarinic receptors

IC50: 2.1 mM for growth inhibition of human buccal epithelial cells

Guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. Guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.

In Vitro: In human buccal epithelial cells, Guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the IC50 value of 2.1 mM. Besides, Guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mM Guvacoline caused 25% decrease) and increase the number of single strand breaks [1].

In Vivo: No data available recently.

Clinical trial: No data available recently.

[1] K.  Sundqvist, Y. Liu, J. Nair, et al. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Research 49(19), 5294-5298 (1989).