HS-PEG3-CH2CH2NH2 (Synonyms: Thiol-PEG3-amine) |
| カタログ番号GC60195 |
HS-PEG3-CH2CH2NH2は、PROTACの合成に使用できるPEGベースのリンカーです。
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Cas No.: 1189760-69-7
Sample solution is provided at 25 µL, 10mM.
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HS-PEG3-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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