Ibrutinib deacryloylpiperidine |
| カタログ番号GC60197 |
イブルチニブ デアクリロイルピペリジン (IBT4A) は、イブルチニブの不純物です。イブルチニブは、IC50 が 0.5 nM の選択的で不可逆的な Btk 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 330786-24-8
Sample solution is provided at 25 µL, 10mM.
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Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].
[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.
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