IDO1/2-IN-1 hydrochloride |
| カタログ番号GC65499 |
IDO1/2-IN-1 塩酸塩 (化合物 4t) は、IDO1 と IDO2 の IC50 がそれぞれ 28 nM と 144 nM の最初の強力な IDO1/IDO2 二重阻害剤です。 IDO1/2-IN-1塩酸塩は抗腫瘍活性を示します。経口活性。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2310286-60-1
Sample solution is provided at 25 µL, 10mM.
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IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active[1].
[1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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