L Moses dihydrochloride (Synonyms: L-45 dihydrochloride) |
| カタログ番号GC50395 |
高親和性かつ選択的なPCAFブロモドメイン阻害剤
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Sample solution is provided at 25 µL, 10mM.
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High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).
Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 PMID:27966810
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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