Lenalidomide-C5-amido-Boc |
| カタログ番号GC63474 |
Lenalidomide-C5-amido-Boc は、CRBN タンパク質の動員に使用される Lenalidomide ベースのセレブロン リガンドです。レナリドマイド-C5-アミド-Boc は、リンカーによってタンパク質のリガンドに接続され、PROTAC を形成します。
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Cas No.: 2138441-25-3
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].
[1]. Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.
[2]. Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.
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