Lenalidomide-C5-NH2 TFA |
| カタログ番号GC64104 |
Lenalidomide-C5-NH2 は、CRBN タンパク質の動員に使用される Lenalidomide ベースのセレブロン リガンドです。レナリドマイド-C5-NH2 は、リンカーによってタンパク質のリガンドに結合して、MDM2 PROTAC デグレーダーなどの PROTAC を形成できます。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481.
[2]. Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466.
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