Lenalidomide-C5-NH2 TFA |
| Katalog-Nr.GC64104 |
Lenalidomid-C5-NH2 ist der Lenalidomid-basierte Cereblon-Ligand, der zur Rekrutierung des CRBN-Proteins verwendet wird. Lenalidomid-C5-NH2 kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um PROTACs zu bilden, wie z. B. MDM2 PROTAC-Abbaumittel.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481.
[2]. Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466.
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