N-Desmethyltamoxifen |
| カタログ番号GC25662 |
N-Desmethyltamoxifenは、人間におけるTamoxifenの主要な代謝物であり、Tamoxifenよりも10倍強力なプロテインキナーゼC（PKC）阻害剤です。また、ヒトAML細胞においてセラミド代謝を強力に調節し、セラミドグリコシル化、加水分解、スフィンゴシンリン酸化を制限します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31750-48-8
Sample solution is provided at 25 µL, 10mM.
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N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
[1] Vertosick FT Jr, et al. J Neurooncol. 1994;19(2):97-103. [2] Morad SA, et al. Biochim Biophys Acta. 2015 Jul;1851(7):919-28.
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