N33-TEG-COOH (N3-TEG-COOH) |
| カタログ番号GC32955 |
N33-TEG-COOH (N3-TEG-COOH) (N3-TEG-COOH) は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。
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Cas No.: 201467-81-4
Sample solution is provided at 25 µL, 10mM.
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N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.
N33-TEG-COOH is a long linker extracted from Reference PMID: 26035625, Compound 7. A PROTAC is a heterobifunctional compound that contains two ligands connected by a linker unit. One ligand binds an E3 ubiquitin ligase protein, while the other ligand binds to the target protein of interest, thereby bringing the ligase and the target in close proximity[1].
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
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