Nat-20(S)-yne (Synonyms: Click Tag Nat-20(S)-yne) |
| カタログ番号GC44321 |
スムーズンド（SMO）は、パッチドと共にハリネズミシグナルを仲介し、Gli転写因子を介して遺伝子発現を調節するGPCR様受容体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1397692-46-4
Sample solution is provided at 25 µL, 10mM.
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Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.
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