Nitromifene (CI628) |
| カタログ番号GC32445 |
ニトロミフェン (CI628) は、エストロゲン受容体 (ER) のアンタゴニストです。
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Cas No.: 10448-84-7
Sample solution is provided at 25 µL, 10mM.
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Nitromifene is an antagonist of estrogen receptor (ER).
Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].
[1]. Ruenitz PC, et al. Characterization of MCF 7 breast cancer cell growth inhibition by the antiestrogen nitromifene (CI 628) and selected metabolites. J Steroid Biochem. 1989 Sep;33(3):365-9.
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