Nocloprost |
| カタログ番号GC44433 |
ノクロプロストは、胃保護作用と潰瘍治癒作用を持つ安定したプロスタグランジンE2アナログです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 79360-43-3
Sample solution is provided at 25 µL, 10mM.
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Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively). Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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