ODM-203 |
| カタログ番号GC64950 |
ODM-203 は、FGFR3/1/2 および VEGFR3/2/1/4 に対してそれぞれ 6、11、16、5、9、26、および 35 nM の IC50 値を持つ、経口活性および選択的 FGFR/VEGFR 阻害剤です。 ODM-203 は強力な抗腫瘍活性を持ち、腫瘍微小環境における免疫応答を活性化します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1430723-35-5
Sample solution is provided at 25 µL, 10mM.
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ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity[1].
[1]. HolmstrÖm TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18(1):28-38.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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