p-Hydroxycinnamic acid (NSC 59260) |
| カタログ番号GC33471 |
p-ヒドロキシケイ皮酸 (NSC 59260) は、一般的な食物フェノールであり、トロンボキサン B2 産生およびリポ多糖誘発プロスタグランジン E2 産生の IC50 はそれぞれ 371 μM、126 μM で、血小板活性を阻害する可能性があります。
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Cas No.: 7400-08-0
Sample solution is provided at 25 µL, 10mM.
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p-Hydroxycinnamic acid (NSC 59260), a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55•2 (SE 4•01) % and 35•6 (SE 2•35) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].
[1]. Luceri C, et al. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63.
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