PARP1-IN-8 |
| カタログ番号GC64578 |
PARP1-IN-8 (化合物 11c) は、97 nM の IC50 を持つ強力な BBB 浸透 PARP1 阻害剤です。 PARP1-IN-8 は、ヒト肺腺癌上皮細胞株 A549 に対して非常に強力な抗増殖活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 836640-15-4
Sample solution is provided at 25 µL, 10mM.
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PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549[1].
PARP1-IN-8 (compound 11c) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].
[1]. Almahli H, Hadchity E, Jaballah MY, Daher R, Ghabbour HA, Kabil MM, Al-Shakliah NS, Eldehna WM. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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