PF-06250112 |
| カタログ番号GC34709 |
PF-06250112 は、IC50 が 0.5 nM の強力で選択性の高い、経口で生物学的に利用可能な BTK 阻害剤であり、BMX 非受容体チロシンキナーゼおよび TEC に対して、それぞれ IC50 が 0.9 nM および 1.2 nM で阻害効果を示します 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609465-89-5
Sample solution is provided at 25 µL, 10mM.
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PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1]. IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]
[1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.
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