Pimethixene maleate |
| カタログ番号GC65296 |
マレイン酸ピメチキセンは、抗ヒスタミンおよび抗セロトニン作動性化合物であり、抗片頭痛剤として作用します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 13187-06-9
Sample solution is provided at 25 µL, 10mM.
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Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.
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