PKR-IN-2 |
| カタログ番号GC33157 |
PKR-IN-2 は、特許 WO2014139144A1、化合物 160 から抽出されたピルビン酸キナーゼ アイソフォーム PKR アクチベーターです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1628428-01-2
Sample solution is provided at 25 µL, 10mM.
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PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of <100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value: <100 nM (AC50)Target: PKR
[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918. [2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.
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