PKUMDL WQ 2101 |
| カタログ番号GC50508 |
3-ホスホグリセラートデヒドロゲナーゼ（PHGDH）の負のアロステリック調節因子
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 304481-72-9
Sample solution is provided at 25 µL, 10mM.
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Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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