(R)-(-)-JQ1 Enantiomer |
| カタログ番号GC63791 |
(R)-(-)-JQ1 エナンチオマーは (+)-JQ1 の立体異性体です。 (+)-JQ1 は両方の BRD4 標的遺伝子の発現を強力に低下させますが、(R)-(-)-JQ1 エナンチオマーは効果がありません。
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Cas No.: 1268524-71-5
Sample solution is provided at 25 µL, 10mM.
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(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.
(R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].
[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
[2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.
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