(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide |
| カタログ番号GC41711 |
N-アシルエタノールアミンは、関連するアシル基に強く影響を受ける多様な生物学的作用を持っています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220556-74-1
Sample solution is provided at 25 µL, 10mM.
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N-Acyl ethanolamines have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning. LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 μM for CB1, CB2, respectively). Although hydrolized by fatty acid amide hydrolase (FAAH; Ki = 9 μM) it also inhibits FAAH and inhibits voltage-gated K+ channels. (R)-(+)-Linoleyl-1'-hydroxy-2'-propylamide is a homolog of LOEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide to produce R-1 methanandamide imparts higher affinity for the CB receptor as well as improved metabolic stability. The physiological actions of this compound have not been evaluated.
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