Ramoplanin Complex (Synonyms: A-16686, MDL 62198)

Ramoplanin complex is a mixture of ramoplanin A1, -A2, and -A3 originally isolated from Actinoplanes that has antibacterial activity.^1,2,3 Ramoplanin complex is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 µg/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 µg/ml).² It inhibits cell wall synthesis in B. subtilis when used at a concentration of 0.5 µg/ml.¹ Ramoplanin complex is effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice with ED₅₀ values of 0.081, 0.14, and approximately 25 mg/kg per day, respectively.

1.Cavalleri, B., Pagani, H., Volpe, G., et al.A-16686, a new antibiotic from actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristicsJ. Antibiot. (Tokyo)37(4)309-317(1984) 2.Pallanza, R., Berti, M., Scotti, R., et al.A-16686, a new antibiotic from actinoplanes. II. Biological propertiesJ. Antibiot. (Tokyo)37(4)318-324(1984) 3.Shin, D., Rew, Y., and Boger, D.L.Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complexProc. Natl. Acad. Sci. USA101(33)11977-11979(2004)