Ramoplanin Complex (Synonyms: A-16686, MDL 62198) |
Catalog No.GC48025
One-Click Copy Product Info
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Ramoplanin Complex is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76168-82-6
Sample solution is provided at 25 µL, 10mM.
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Ramoplanin complex is a mixture of ramoplanin A1, -A2, and -A3 originally isolated from Actinoplanes that has antibacterial activity.1,2,3 Ramoplanin complex is active against clinical isolates of the Gram-positive bacteria S. aureus, S. pyogenes, S. pneumoniae, and S. faecalis (MICs = 0.016-2 µg/ml) but not Gram-negative bacteria or C. albicans (MICs = ≥128 µg/ml).2 It inhibits cell wall synthesis in B. subtilis when used at a concentration of 0.5 µg/ml.1 Ramoplanin complex is effective against systemic S. pyogenes, S. pneumoniae, and S. aureus infections in mice with ED50 values of 0.081, 0.14, and approximately 25 mg/kg per day, respectively.
1.Cavalleri, B., Pagani, H., Volpe, G., et al.A-16686, a new antibiotic from actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristicsJ. Antibiot. (Tokyo)37(4)309-317(1984) 2.Pallanza, R., Berti, M., Scotti, R., et al.A-16686, a new antibiotic from actinoplanes. II. Biological propertiesJ. Antibiot. (Tokyo)37(4)318-324(1984) 3.Shin, D., Rew, Y., and Boger, D.L.Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complexProc. Natl. Acad. Sci. USA101(33)11977-11979(2004)
| Cas No. | 76168-82-6 | SDF | |
| Synonyms | A-16686, MDL 62198 | ||
| Canonical SMILES | OC(C=C1)=CC=C1[C@H](C(N[C@H](CCCN)C(N[C@@]([C@H](O)C)([H])C(N[C@@H](C2=CC=C(O)C=C2)C(N[C@H](C3=CC=C(O)C=C3)C(NC([C@H](C)O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](CCCN)C(N[C@@H](C5=CC=C(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O[C@]7([H])[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)C=C5)C8=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC(/C=C\C=C\CCC)=O)CC(N)=O)=O)[C@@H](C(N)=O)OC([C@]([H])(C9=CC=C(O)C(Cl)=C9)NC([C@@H](C)NC([C@H](CC(C)C)NC(CNC([C@H](C%10=CC=C(O)C=C%10)NC([C@]([C@H](O)C)([H])N8)=O)=O)=O)=O)=O)=O)=O.OC(C=C%11)=CC=C%11[C@H](C(N[C@H](CCCN)C(N[C@@]([C@H](O)C)([H])C(N[C@@H](C%12=CC=C(O)C=C%12)C(N[C@H](C%13=CC=C(O)C=C%13)C(NC([C@H](C)O)C(N[C@@H](CC%14=CC=CC=C%14)C(N[C@H](CCCN)C(N[C@@H](C%15=CC=C(O[C@H]%16O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%16O[C@]%17([H])[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%17)C=C%15)C%18=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC(/C=C\C=C\CC(C)C)=O)CC(N)=O)=O)[C@@H](C(N)=O)OC([C@]([H])(C%19=CC=C(O)C(Cl)=C%19)NC([C@@H](C)NC([C@H](CC(C)C)NC(CNC([C@H](C%20=CC=C(O)C=C%20)NC([C@]([C@H](O)C)([H])N%18)=O)=O)=O)=O)=O)=O)=O.OC(C=C%21)=CC=C%21[C@H](C(N[C@H](CCCN)C(N[C@@]([C@H](O)C)([H])C(N[C@@H](C%22=CC=C(O)C=C%22)C(N[C@H](C%23=CC=C(O)C=C%23)C(NC([C@H](C)O)C(N[C@@H](CC%24=CC=CC=C%24)C(N[C@H](CCCN)C(N[C@@H](C%25=CC=C(O[C@H]%26O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%26O[C@]%27([H])[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%27)C=C%25)C%28=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC(/C=C\C=C\CCC(C)C)=O)CC(N)=O)=O)[C@@H](C(N)=O)OC([C@]([H])(C%29=CC=C(O)C(Cl)=C%29)NC([C@@H](C)NC([C@H](CC(C)C)NC(CNC([C@H](C%30=CC=C(O)C=C%30)NC([C@]([C@H](O)C)([H])N%28)=O)=O)=O)=O)=O)=O)=O | ||
| Formula | C119H154ClN21O40 (for A2) | M.Wt | 2554.1 |
| Solubility | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 391.5 μL | 1.9576 mL | 3.9153 mL |
| 5 mM | 78.3 μL | 391.5 μL | 783.1 μL |
| 10 mM | 39.2 μL | 195.8 μL | 391.5 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% & >80% (Ramoplanin A2) Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)