Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

対象は Porcupine

製品は Porcupine

Cat.No. 商品名 インフォメーション
GC32877 GNF-6231 GNF-6231 は、Wnt シグナル伝達をブロックする、強力で選択的な経口投与可能なヤマアラシ阻害剤です。
GC17708 IWP-L6 IWP-L6 (Porcn Inhibitor III) は、EC50 が 0.5 nM の Porcn 阻害剤です。
GC34628 IWP-O1 IWP-O1 は非常に強力なヤマアラシ (Porcn) 阻害剤であり、L-Wnt-STF 細胞での EC50 は 80 pM です。 IWP-O1 は、Wnt タンパク質の分泌を防ぎます。 IWP-O1 は、HeLa 細胞における Dvl2/3 および LRP6 のリン酸化を抑制します。
GC12392 LGK-974
PORCN阻害剤、強力かつ特異的
GC19299 Porcupine-IN-1 Porcupine-IN-1 は、IC50 が 0.5±0.2 nM の強力な Porcupine 阻害剤です。
GC13658 Wnt-C59 Wnt-C59 (C59) は、IC50 が 74 pM の非常に強力な経口ヤマアラシ (PORCN) 阻害剤です。