SBI-425 |
| カタログ番号GC38846 |
SBI-425 は、経口活性で強力な TNAP (組織非特異的アルカリホスファターゼ) 阻害剤です (IC50=16 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1451272-71-1
Sample solution is provided at 25 µL, 10mM.
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SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].
[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. [2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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