Solanidine (Synonyms: (-)-Solanidine, 22R,25S-Solanidine, NSC 76025) |
カタログ番号GC52075
One-Click Copy Product Info
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ソラニジンは、Solanum demissum、Solanum acaule、Solanum tuberosum などのいくつかのジャガイモ種から分離されたコレスタン アルカロイドです。ソラニジンは増殖を阻害し、明らかな抗腫瘍効果を発揮します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 80-78-4
Sample solution is provided at 25 µL, 10mM.
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Solanidine is a steroidal glycoalkaloid metabolite that has been found in potato (S. tuberosum) and has anticancer and teratogenic activities.1,2,3 It inhibits the growth of HT-29 colon and HepG2 liver cancer cells by 80.9 and 82.2%, respectively, when used at a concentration of 100 μg/ml.2 Solanidine (176 mg/kg) is teratogenic to hamster embryos when administered to pregnant dams on day eight of gestation.3
1.Nikolic, N.C., and Stankovic, M.Z.Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systemsJ. Agric. Food Chem.51(7)1845-1849(2003) 2.Lee, K.-R., Kozukue, N., Han, J.-S., et al.Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cellsJ. Agric. Food Chem.52(10)2832-2839(2004) 3.Gaffield, W., and Keeler, R.F.Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesisExperientia49(10)922-924(1993)
| Cas No. | 80-78-4 | SDF | |
| 同義語 | (-)-Solanidine, 22R,25S-Solanidine, NSC 76025 | ||
| Canonical SMILES | C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC2)([H])N6[C@@](CC[C@@H](C6)C)([H])[C@H]3C | ||
| Formula | C27H43NO | M.Wt | 397.6 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5151 mL | 12.5755 mL | 25.1509 mL |
| 5 mM | 503 μL | 2.5151 mL | 5.0302 mL |
| 10 mM | 251.5 μL | 1.2575 mL | 2.5151 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)