SPDP (SPDP Crosslinker) |
| カタログ番号GC30018 |
SPDP (SPDP Crosslinker) (SPDP (SPDP Crosslinker) Crosslinker) は、システイン スルフヒドリルとの切断可能な (還元可能な) ジスルフィド結合を形成する NHS-エステルおよびピリジルジチオール反応基を介したアミン-スルフヒドリル結合のための短鎖架橋剤です。これは、抗体薬物複合体 (ADC) に使用されるグルタチオン切断可能な ADC リンカーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68181-17-9
Sample solution is provided at 25 µL, 10mM.
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SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.
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