SPDP (SPDP Crosslinker) |
| Catalog No.GC30018 |
SPDP(SPDP 가교제)(SPDP(SPDP 가교제) 가교제)는 NHS-에스테르 및 피리딜디티올 반응성 기를 통한 아민-설프히드릴 접합을 위한 단쇄 가교제로서 시스테인 설프하이드릴과 절단 가능한(환원 가능한) 이황화 결합을 형성합니다. 항체-약물 접합체(ADC)에 사용되는 글루타티온 절단 가능한 ADC 링커입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68181-17-9
Sample solution is provided at 25 µL, 10mM.
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SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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