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SPDP (SPDP Crosslinker) Catalog No.GC30018

Size Price Stock Qty
10mg
$49.00
In stock
50mg
$134.00
In stock
100mg
$223.00
In stock
200mg
$321.00
In stock
500mg
$669.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 68181-17-9 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Formula C12H12N2O4S2 M.Wt 312.36
Solubility DMSO : 155 mg/mL (496.22 mM; Need ultrasonic) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.