Syk Inhibitor (Synonyms: OXSI 2, Spleen Tyrosine Kinase) |
| カタログ番号GC44977 |
Syk Inhibitor は、313 nM の EC50 と 14 nM の IC50 を持つ、生物学的に利用可能な細胞透過性の Syk 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 622387-85-3
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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