Syk Inhibitor (Synonyms: OXSI 2, Spleen Tyrosine Kinase) |
| Catalog No.GC44977 |
Syk 억제제는 EC50이 313nM이고 IC50이 14nM인 생체이용 가능한 세포 투과성 Syk 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 622387-85-3
Sample solution is provided at 25 µL, 10mM.
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Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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