TASP 0433864 |
| カタログ番号GC50150 |
TASP 0433864 は、代謝型グルタミン酸 2 (mGlu2) 受容体の選択的ポジティブ アロステリック モジュレーター (PAM) であり、EC50 値は、ヒトおよびラットの mGlu2 受容体に対してそれぞれ 199 nM および 206 nM です。
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Cas No.: 1431980-60-7
Sample solution is provided at 25 µL, 10mM.
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Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
Hiyoshi et al (2014) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 351 642 PMID:25277141
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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