ML204 hydrochloride |
| カタログ番号GC36627 |
ML204 塩酸塩は、TRPC6 に対して少なくとも 19 倍の選択性を持ち、他のすべての TRP チャネルや、電位依存性ナトリウム、カリウム、または Ca2+ チャネルには顕著な影響を及ぼさない、新規の強力な選択的 TRPC4/TRPC5 チャネル阻害剤です。 .
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Cas No.: 2070015-10-8
Sample solution is provided at 25 µL, 10mM.
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ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays.target: ML204IC50: 0.96 uMIn vitro: ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise.ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2]In vivo: The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]
[1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program.
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