Tislelizumab |
| カタログ番号GC65033 |
PD-1受容体に対して高い結合親和性を持つモノクローナル抗体であるティスレリズマブは、マクロファージ上のFcγ受容体結合を最小限に抑え、それによって抗体依存性食作用、T細胞クリアランスのメカニズム、および抗PD-1療法に対する潜在的な耐性を無効にします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1858168-59-8
Sample solution is provided at 25 µL, 10mM.
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Tislelizumab, a monoclonal antibody with high binding affinity to the PD-1 receptor, minimizes Fcγ receptor binding on macrophages, thereby abrogating antibody-dependent phagocytosis, a mechanism of T cell clearance and potential resistance to anti-PD-1 therapy. Tislelizumab can be used for the research of advanced squamous non-small-cell lung cancer[1].
[1]. Jie Wang, et al. Tislelizumab Plus Chemotherapy vs Chemotherapy Alone as First-line Treatment for Advanced Squamous Non-Small-Cell Lung Cancer: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2021 May 1;7(5):709-717.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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