Tislelizumab |
| Katalog-Nr.GC65033 |
Tislelizumab, ein monoklonaler AntikÖrper mit hoher BindungsaffinitÄt zum PD-1-Rezeptor, minimiert die Fcγ-Rezeptorbindung an Makrophagen und hebt dadurch die antikÖrperabhÄngige Phagozytose auf, einen Mechanismus der T-Zell-Clearance und potenzielle Resistenz gegen eine Anti-PD-1-Therapie.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1858168-59-8
Sample solution is provided at 25 µL, 10mM.
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Tislelizumab, a monoclonal antibody with high binding affinity to the PD-1 receptor, minimizes Fcγ receptor binding on macrophages, thereby abrogating antibody-dependent phagocytosis, a mechanism of T cell clearance and potential resistance to anti-PD-1 therapy. Tislelizumab can be used for the research of advanced squamous non-small-cell lung cancer[1].
[1]. Jie Wang, et al. Tislelizumab Plus Chemotherapy vs Chemotherapy Alone as First-line Treatment for Advanced Squamous Non-Small-Cell Lung Cancer: A Phase 3 Randomized Clinical Trial. JAMA Oncol. 2021 May 1;7(5):709-717.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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