TNF-α Antagonist (Synonyms: WP9QY) |
| カタログ番号GC45062 |
TNF-α拮抗剤は、TNF受容体I複合体上の重要なTNF-α認識ループを模倣し、そのためにリガンドが受容体と相互作用することを防止する外環式ペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 199999-60-5
Sample solution is provided at 25 µL, 10mM.
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TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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