Tyr-α-CGRP (human) (trifluoroacetate salt) (Synonyms: Tyr0-CGRP (human)) |
| カタログ番号GC45096 |
Tyr-α-CGRPは、αカルシトニン遺伝子関連ペプチドのN末端拡張されたチロシン化アナログです。
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Cas No.: 124756-98-5
Sample solution is provided at 25 µL, 10mM.
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Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).
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